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this residue is hydrogen bonded to your lone h2o molecule (or hydroxide) that is certainly coordinated to your metallic ion bound to the Mβ-web site (21). Hence, it is expected that this residue will function in catalysis by abstraction of the proton from water ahead of, or concomitant with, the attack of hydroxide around the amide bond from the substrate. Within the detection limitations of our assay for solution formation, we were being not able to measure any catalytic activity for either the D273N or D273A mutant.
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Within the 1998 movie Jungle Boy, the Naga is depicted as a large cobra deity that grants the gift of knowing all languages to those who are pure of coronary heart and punishes those who are not pure of coronary heart in various ways.
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Born someplace around 1905 (the exact day of his start is unknown) in Kambiron village of current-working day Tamenglong district in Manipur into a weak peasant household with the Malangmei clan from the Rongmei Naga tribe, Jadonang was the youngest of 3 sons.
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